HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenyl Ether → Ethyl 6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | 2-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester | HCID 618981 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Ethyl 6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 228284 | 44.7% |
Reaction Steps
Diethyl (4-methoxyphenylaminomethylene)malonate (5.18 g, 17.9 mmol) is added to phenyl ether (22 mL) preheated to 250° C. Heating is continued for 70 minutes. The reaction mixture is allowed to cool, diethyl ether is added, and the precipitate is collected, rinsed with diethyl ether and dried to afford 1.98 g of ethyl 6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06413956B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-8da46fd8947643a2899290f8ec0d84cd |
| Source note | uspto-grants-2002_07 |