反应详情

Diethyl (4-methoxyphenylaminomethylene)malonate (5.18 g, 17.9 mmol) is added to phenyl ether (22 mL) preheated to 250° C. Heating is continued for 70 minutes. The reaction mixture is allowed to cool, diethyl ether is added, and the precipitate is collected, rinsed with diethyl ether and dried to afford 1.98 g of ethyl 6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylate.

1. custompreheated to 250° C
2. temperatureHeating
3. temperatureto cool
4. customthe precipitate is collected
5. washrinsed with diethyl ether
6. customdried