HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 228284 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID | HCID 255289 | 87.4% |
Reaction Steps
A mixture of ethyl 6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylate (1.22 g, 4.96 mmol), 1N NaOH (25 mL), and ethanol (5 mL) is heated at reflux for 1.5 h. The reaction mixture is cooled in an ice bath, acidified with aqueous HCl, and the precipitate is collected, rinsed with water and dried to give 0.95 g of 6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06413956B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-2060e8c68ca24dcea6390d3260aaf16e |
| Source note | uspto-grants-2002_07 |