反应详情

A mixture of ethyl 6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylate (1.22 g, 4.96 mmol), 1N NaOH (25 mL), and ethanol (5 mL) is heated at reflux for 1.5 h. The reaction mixture is cooled in an ice bath, acidified with aqueous HCl, and the precipitate is collected, rinsed with water and dried to give 0.95 g of 6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid.

1. temperatureis heated
2. temperatureat reflux for 1.5 h
3. temperatureThe reaction mixture is cooled in an ice bath
4. customthe precipitate is collected
5. washrinsed with water
6. customdried