HCID 70158897, compound → HCID 70159230, compound

HRID 2227278Notes

Reaction equation

HRID 2227278 reaction equation
[CH2:1]([O:3][C:4](=[O:33])[CH2:5][C@@H:6]([C:25]1[CH:26]=[N:27][C:28]([O:31][CH3:32])=[CH:29][CH:30]=1)[CH:7]=[CH:8][CH2:9][N:10]1[C@H:14]([CH3:15])[CH2:13][C@H:12]([NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:11]1=[O:24])[CH3:2]>CO.C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:33])[CH2:5][C@@H:6]([C:25]1[CH:26]=[N:27][C:28]([O:31][CH3:32])=[CH:29][CH:30]=1)[CH2:7][CH2:8][CH2:9][N:10]1[C@H:14]([CH3:15])[CH2:13][C@H:12]([NH:16][C:17]([O:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[O:18])[C:11]1=[O:24])[CH3:2]

Participants

5

Reactant 1

HCID 70158897HCID 70158897, compound

Product 1

HCID 70159230HCID 70159230, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

To stirred solution of 4-6 (250 mg) in methanol (15 mL) was added a suspension of 10% Pd on carbon (90 mg) in ethanol (2 mL). The resulting suspension was stirred under an atmosphere of hydrogen for 1.5 hours. The mixture was filtered through Celite. The solvent was evaporated to give 4-7 as a colorless oil.

Workup

  1. additionwas added
  2. filtrationThe mixture was filtered through Celite
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-705f7ff7e219400495cd826badf36164
Source dataset
uspto-grants-2002_07
Patent number
US06413955B1

Reaction notes

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