HCID 70159372, compound → HCID 70159444, compound

HRID 2227284Notes

Reaction equation

HRID 2227284 reaction equation
[CH2:1]([O:3][C:4](=[O:32])[CH2:5][C@@H:6]([C:25]1[CH:26]=[N:27][C:28]([CH3:31])=[N:29][CH:30]=1)[CH:7]=[CH:8][CH2:9][N:10]1[C@H:14]([CH3:15])[CH2:13][C@H:12]([NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:11]1=[O:24])[CH3:2]>CO.C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:32])[CH2:5][C@@H:6]([C:25]1[CH:26]=[N:27][C:28]([CH3:31])=[N:29][CH:30]=1)[CH2:7][CH2:8][CH2:9][N:10]1[C@H:14]([CH3:15])[CH2:13][C@H:12]([NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:21])[CH3:22])=[O:18])[C:11]1=[O:24])[CH3:2]

Participants

5

Reactant 1

HCID 70159372HCID 70159372, compound

Product 1

HCID 70159444HCID 70159444, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

To stirred solution of 5-3 (180 mg) in methanol (8 mL) was added a suspension of 10% Pd on carbon (60 mg) in ethanol (1 mL). The resulting suspension was stirred under an atmosphere of hydrogen for 1.5 hours. The mixture was filtered through Celite. The solvent was evaporated to give 5-4 as an oil.

Workup

  1. additionwas added
  2. filtrationThe mixture was filtered through Celite
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-666cbf38453744b6ba9f5634eeb712fd
Source dataset
uspto-grants-2002_07
Patent number
US06413955B1

Reaction notes

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