Butylamine → 2-Chloro-6-[(butyl)amino]-9-(2-propyl)purine

HRID 2227323Notes

Reaction equation

HRID 2227323 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4](Cl)[N:3]=1.[CH2:15]([NH2:19])[CH2:16][CH2:17][CH3:18]>C(N(CC)CC)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4]([NH:19][CH2:15][CH2:16][CH2:17][CH3:18])[N:3]=1

Participants

4

Reactant 2

HCID 8007ButylamineHCID 112184902,6-dichloro-9-(propan-2-yl)-9H-purine

Product 1

HCID 542103652-Chloro-6-[(butyl)amino]-9-(2-propyl)purine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Chloro-6-[(butyl)amino]-9-(2-propyl)purine is prepared from 2,6-dichloro-9-(2-propyl)purine (see Example 15 for preparation), butylamine, and triethylamine essentially as described above in Example 1, Scheme A, step b.

Sources & evidence

ORD record
ord-a5ef33d90d9b4c83ac3ba07b48bb3c53
Source dataset
uspto-grants-2002_07
Patent number
US06413974B1

Reaction notes

Loading…