4-Chloro-2-fluorobenzylamine → HCID 18473395, compound

HRID 2227324Notes

Reaction equation

HRID 2227324 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[Cl:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][NH2:23])=[C:20]([F:26])[CH:19]=1>C(N(CC)CC)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4]([NH:23][CH2:22][C:21]2[CH:24]=[CH:25][C:18]([Cl:17])=[CH:19][C:20]=2[F:26])[N:3]=1

Participants

4

Reactant 2

HCID 27249104-Chloro-2-fluorobenzylamineHCID 108011162,6-dichloro-9-cyclopentyl-9H-purine

Product 1

HCID 18473395HCID 18473395, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Chloro-6-[(4-chloro-2-fluorobenzyl)amino]-9-cyclopentylpurine is prepared from 2,6-dichloro-9-cyclopentylpurine, 4-chloro-2-fluorobenzylamine, and triethylamine essentially as described above in Example 1, Scheme A, step b.

Sources & evidence

ORD record
ord-d87ca71bd4234a7082a49d27046204b4
Source dataset
uspto-grants-2002_07
Patent number
US06413974B1

Reaction notes

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