Benzylamine → N-Benzyl-2-chloro-9-isopropyl-9H-purin-6-amine

HRID 2227329Notes

Reaction equation

HRID 2227329 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4](Cl)[N:3]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(N(CC)CC)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4]([NH:22][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 112184902,6-dichloro-9-(propan-2-yl)-9H-purine

Product 1

HCID 10733091N-Benzyl-2-chloro-9-isopropyl-9H-purin-6-amine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Chloro-6-(benzylamino)-9-(2-propyl)purine is prepared from 2,6-dichloro-9-(2-propyl)purine (see Example 15 for preparation), benzylamine, and triethylamine essentially as described above in Example 1, Scheme A, step b.

Sources & evidence

ORD record
ord-8b6d907e7e5049d5affb67deb0257fb5
Source dataset
uspto-grants-2002_07
Patent number
US06413974B1

Reaction notes

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