1-Methylimidazole → 2-Fluoro-4-(hydroxy(1-methyl-1h-imidazol-5-yl)methyl)benzonitrile

Temperature

-78 °C

1-Methylimidazole (15.88 mL, 0.199 mol), dissolved in anhydrous THF (500 mL) in flame-dried glassware under Ar, was cooled to −78° C. and treated with n-butyl lithium (1.6M in hexane)(124 mL, 0.199 mol) via syringe. After stirring for 1 hr chlorotriethylsilane (33.4 mL, 0.199 mol) was added and the reaction mixture was left to warm to ambient temperature overnight. The THF was removed in vacuo with gentle warming, and the residue was redissolved in dry THF (500 mL), cooled to −78° C., and treated with sec-butyl lithium (1.3M in cyclohexane) (153 mL, 0.199 mol) dropwise. After 1 hr this solution was cannulated into a solution of 2-fluoro-4-formylbenzonitrile (27 g, 0.181 mol) in THF (200 mL). After 15 min the cooling bath was removed, the mixture was stirred for 2 hr at ambient temperature, then was quenched with saturated NH4Cl solution. After 15 min 10% HCl was added to pH=3. After 0.5 hr the THF was removed in vacuo, the mixture was made basic with solid Na2CO3 and extracted with EtOAc (3×200 mL). The organics were combined, washed with 10% HCl (3×), the aqueous acidic layers combined, made basic with solid Na2CO3, extracted with EtOAc (3×), the organics combined, washed with brine, and dried (MgSO4). Filtration and concentration to dryness gave the title compound.

1. additionwas added
2. waitthe reaction mixture was left
3. temperatureto warm to ambient temperature overnight
4. customThe THF was removed in vacuo with gentle warming
5. dissolutionthe residue was redissolved in dry THF (500 mL)
6. temperaturecooled to −78° C.
7. customAfter 15 min the cooling bath was removed
8. customwas quenched with saturated NH4Cl solution
9. additionAfter 15 min 10% HCl was added to pH=3
10. customAfter 0.5 hr the THF was removed in vacuo
11. extractionextracted with EtOAc (3×200 mL)
12. washwashed with 10% HCl (3×)
13. extractionextracted with EtOAc (3×)
14. washwashed with brine
15. dry with materialdried (MgSO4)
16. filtrationFiltration and concentration to dryness

ORD record

ord-309b5cc5ddbe4d9490218892c0835f21

Source dataset

uspto-grants-2002_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06413964B1