Hydrochloric Acid → HCID 22315573, compound

HRID 2227409Notes

Reaction equation

HRID 2227409 reaction equation
[Cl:1][CH:2]([Cl:7])[C:3](OC)=[O:4].C[O-].[Na+].[F:11][C:12]1[CH:13]=[C:14]([C:20](=[O:22])[CH3:21])[CH:15]=[CH:16][C:17]=1[O:18][CH3:19].Cl>CCOCC>[Cl:7][CH:2]([Cl:1])[C:3](=[O:4])[CH2:21][C:20]([C:14]1[CH:15]=[CH:16][C:17]([O:18][CH3:19])=[C:12]([F:11])[CH:13]=1)=[O:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8315Methyl dichloroacetateHCID 968281-(3-Fluoro-4-methoxyphenyl)ethan-1-oneHCID 10942334Sodium Methoxide

Product 1

HCID 22315573HCID 22315573, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Methyl dichloroacetate (1.57 g, 11 mmol) was dissolved ether (25 mL). To the stirred solution was added 25% sodium methoxide (2.38 g, 11 mmol) followed by 3′-fluoro-4′-methoxyacetophenone from Step 1 (1.68 g, 10 mmol). After stirring 16 hours 1N HCl (25 mL) was added. The organic layer was collected and washed with water (2×25 mL), dried over magnesium sulfate, filtered, and concentrated. The resulting crude dione was used in the next step without further purification or characterization.

Workup

  1. additionwas added
  2. customThe organic layer was collected
  3. washwashed with water (2×25 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe resulting crude dione was used in the next step without further purification or characterization

Sources & evidence

ORD record
ord-12805414981f4562b5e8a9b4a6bf4b98
Source dataset
uspto-grants-2002_07
Patent number
US06413960B1

Reaction notes

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