Ethyl Acetate → HCID 12082818, compound

HRID 2227414Notes

Reaction equation

HRID 2227414 reaction equation
F[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:4]=1.C(OCC)(=[O:26])C>O=[Mn]=O>[CH:2]([C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:4]=1)=[O:26]

Participants

4

Reactant 2

HCID 8857Ethyl AcetateHCID 10520508HCID 10520508, compound

Product 1

HCID 12082818HCID 12082818, compound

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Procedure

To a solution of the alcohol prepared in Example 131, Step 3 (1.1 g, 3.3 mmol) in ethyl acetate (20 mL) was added MnO2 (5 g, 60 mmol) and the mixture stirred at room temperature overnight. The mixture was filtered through Celite and the solution was concentrated to provide the crude aldehyde.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-86ab9e0b3d194b7387c52b87c08f709c
Source dataset
uspto-grants-2002_07
Patent number
US06413960B1

Reaction notes

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