2-Amino-5-bromopyrazine → 7-[(5-Bromo-2-pyrazinyl)oxy]-3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepine

HRID 222743Notes

Reaction equation

HRID 222743 reaction equation
[CH:1]1([N:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[C:13]([OH:16])[CH:14]=[CH:15][C:8]=3[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[Br:17][C:18]1[N:19]=[CH:20][C:21](N)=[N:22][CH:23]=1>>[Br:17][C:18]1[N:19]=[CH:20][C:21]([O:16][C:13]2[CH:14]=[CH:15][C:8]3[CH2:7][CH2:6][N:5]([CH:1]4[CH2:4][CH2:3][CH2:2]4)[CH2:11][CH2:10][C:9]=3[CH:12]=2)=[N:22][CH:23]=1

Participants

3

Reactant 2

HCID 5995392-Amino-5-bromopyrazineHCID 100820813-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[D]azepin-7-OL

Product 1

HCID 103847687-[(5-Bromo-2-pyrazinyl)oxy]-3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Procedure

The title compound was prepared from 3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (E3) and 2,5-dibromopyrazine (D48) using the method of Example 257 (E257); MS (ES+) m/e 375 [M+H]+.

Sources & evidence

ORD record
ord-583bf623f0544a01bccd43d57cd3fb76
Source dataset
uspto-grants-2012_06
Patent number
US08207331B2

Reaction notes

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