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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 222743Generated: October 30, 2026

2-Amino-5-bromopyrazine → 7-[(5-Bromo-2-pyrazinyl)oxy]-3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepine

https://huagongshe.com/reaction/222743

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-5-bromopyrazineHCID 599539—
Reactant3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[D]azepin-7-OLHCID 10082081—
Product7-[(5-Bromo-2-pyrazinyl)oxy]-3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 10384768—

Reaction Steps

The title compound was prepared from 3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (E3) and 2,5-dibromopyrazine (D48) using the method of Example 257 (E257); MS (ES+) m/e 375 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08207331B2
Source datasetuspto-grants-2012_06
ORD IDord-583bf623f0544a01bccd43d57cd3fb76
Source noteuspto-grants-2012_06