反应详情

To a solution in dichloromethane (10 ml) of the compound (239 mg) obtained in Example 1b, triphenyl phosphine (345 mg) and carbon tetrabromide (436 mg) were sequentially added dropwise under cooling with ice. The reaction mixture was stirred for 2 hours under cooling with ice and then concentrated at reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent; ethyl acetate:n-hexane=1:9) to give the titled compound (yield,47%).

1. temperatureunder cooling with ice
2. temperatureunder cooling with ice
3. concentrationconcentrated at reduced pressure
4. customThe resulting residue was purified by silica gel column chromatography (eluent; ethyl acetate:n-hexane=1:9)