Ethanol hydrochloride → HCID 178468350, compound

HRID 2227478Notes

Reaction equation

C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([NH:15][C:16]#[N:17])[CH:12]=[CH:11][C:10]=1[N:18]1[CH:22]=[CH:21][CH:20]=[N:19]1)(C)(C)C.[ClH:24].[CH2:25]([OH:27])[CH3:26]>>[ClH:24].[ClH:24].[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([NH:15][C:16](=[NH:17])[O:27][CH2:25][CH3:26])[CH:12]=[CH:11][C:10]=1[N:18]1[CH:22]=[CH:21][CH:20]=[N:19]1

Participants

Reactant 2

HCID 21887872Ethanol hydrochloride

HCID 54233451HCID 54233451, compound

Product 1

HCID 178468350HCID 178468350, compoundYield 61%

Procedure

A mixture of the compound (243 mg) obtained in Example 4a and saturated HCl-ethanol (10 ml) was stirred at room temperature for 29 hours. The reaction mixture was concentrated at reduced pressure and the resulting residue was recrystallized from ethanol-ethyl acetate to give the titled compound (yield, 61%).

Workup

concentrationThe reaction mixture was concentrated at reduced pressure
customthe resulting residue was recrystallized from ethanol-ethyl acetate

Sources & evidence

ORD record: ord-b872c31624a8441395b64f4080b8892c
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06414005B1

Reaction notes

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