Triethylamine → HCID 4531450, compound

HRID 2227486Notes

Reaction equation

HRID 2227486 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1.[F:9][C:10]([F:17])([F:16])[C:11](OCC)=[O:12].C(N(CC)CC)C>ClCCl>[N:5]1[CH:6]=[CH:7][CH:8]=[C:3]([CH2:2][NH:1][C:11](=[O:12])[C:10]([F:17])([F:16])[F:9])[CH:4]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 9794Ethyl trifluoroacetateHCID 310183-Pyridinemethanamine

Product 1

HCID 4531450HCID 4531450, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

22.87 g of 3-(aminomethyl)pyridine was dissolved in 100 ml dichloromethane and stirred with 50.4 ml ethyl trifluoroacetate and 29.5 ml triethylamine at room temperature for 2 hours. The solvent was evaporated under reduced pressure to give a residue, which was then recrystallized from ethyl acetate to provide N-(3-pyridylmethyl)trifluoroacetic acid amide (40.15 g, 93%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customto give a residue, which
  3. customwas then recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-6131815137894b959686a8441e094a4d
Source dataset
uspto-grants-2002_07
Patent number
US06413995B1

Reaction notes

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