反应详情

To 2,6-dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)amino phenol (8 g), acetic acid (2.8 ml), and aqueous 40% formaldehyde (3.1 ml) in acetonitrile (40 ml) was added sodium cyanoborohydride (5.4 g). After 2 hours the mixure was quenched with water and extracted with dichloromethane. The organic phase was washed with aqueous sodium bicarbonate solution, then water, dried, evaporated and chromatographed (silica, dichloromethane) to give the title product (3 g), mp 139°-140° (from ethanol).

1. customAfter 2 hours the mixure was quenched with water
2. extractionextracted with dichloromethane
3. washThe organic phase was washed with aqueous sodium bicarbonate solution
4. dry with materialwater, dried
5. customevaporated
6. customchromatographed (silica, dichloromethane)