Hydrochloric Acid → HCID 18473837, compound

Participants

Reaction Steps

0.23 g of ethyl 3-hydroxy-3-[4-(methoxymethoxy)phenyl]-3-phenylpropionate was dissolved in 1 ml ethanol, and then stirred with 14 ml of 2 mol/l aqueous sodium hydroxide at room temperature for 16 hours. The reaction mixture was adjusted to pH 1 with concentrated hydrochloric acid, extracted with ethyl acetate three times, washed twice with water and once with brine, followed by drying over anhydrous magnesium sulfate. The drying agent was filtered off and the solvent was evaporated to give 3-hydroxy-3-[4-(methoxymethoxy)phenyl]-3-phenylpropionic acid (202 mg, yield: 95.7%) as a white solid.

Provenance & Evidence