Hydrochloric Acid → HCID 18473837, compound

HRID 2227508Notes

Reaction equation

HRID 2227508 reaction equation
[OH:1][C:2]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][O:23][CH3:24])=[CH:17][CH:16]=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4]([O:6]CC)=[O:5].[OH-].[Na+].Cl>C(O)C>[OH:1][C:2]([C:15]1[CH:16]=[CH:17][C:18]([O:21][CH2:22][O:23][CH3:24])=[CH:19][CH:20]=1)([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[CH2:3][C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18473835HCID 18473835, compound

Product 1

HCID 18473837HCID 18473837, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.23 g of ethyl 3-hydroxy-3-[4-(methoxymethoxy)phenyl]-3-phenylpropionate was dissolved in 1 ml ethanol, and then stirred with 14 ml of 2 mol/l aqueous sodium hydroxide at room temperature for 16 hours. The reaction mixture was adjusted to pH 1 with concentrated hydrochloric acid, extracted with ethyl acetate three times, washed twice with water and once with brine, followed by drying over anhydrous magnesium sulfate. The drying agent was filtered off and the solvent was evaporated to give 3-hydroxy-3-[4-(methoxymethoxy)phenyl]-3-phenylpropionic acid (202 mg, yield: 95.7%) as a white solid.

Workup

  1. extractionextracted with ethyl acetate three times
  2. washwashed twice with water and once with brine
  3. dry with materialby drying over anhydrous magnesium sulfate
  4. filtrationThe drying agent was filtered off
  5. customthe solvent was evaporated

Sources & evidence

ORD record
ord-a26564f51904412faf52ad2d190f7608
Source dataset
uspto-grants-2002_07
Patent number
US06413995B1

Reaction notes

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