Hydrochloric Acid → 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-(1-methylcyclopent-1-yl) ketone hydrochloride

HRID 2227667Notes

Reaction equation

HRID 2227667 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH:11]3[CH2:15][CH2:14][CH2:13][C:12]3([C:17]([C:19]3([CH3:44])[CH2:23][CH2:22][CH2:21][CH:20]3[C:24]3[CH:43]=[CH:42][C:27]4[N:28]([CH3:41])[C:29]([CH2:31][NH:32][C:33]5[CH:38]=[CH:37][C:36]([C:39]#[N:40])=[CH:35][CH:34]=5)=[N:30][C:26]=4[CH:25]=3)=[O:18])[CH3:16])=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:45][NH:46][C:47]1[CH:52]=[CH:51][C:50]([C:53]#[N:54])=[CH:49][CH:48]=1.[ClH:55].C(=O)([O-])[O-].[NH4+:60].[NH4+:61]>C(O)C>[ClH:55].[CH3:41][N:28]1[C:27]2[CH:42]=[CH:43][C:24]([CH:20]3[CH2:21][CH2:22][CH2:23][C:19]3([C:17]([C:12]3([CH3:16])[CH2:13][CH2:14][CH2:15][CH:11]3[C:9]3[CH:8]=[CH:7][C:6]4[N:2]([CH3:1])[C:3]([CH2:45][NH:46][C:47]5[CH:52]=[CH:51][C:50]([C:53](=[NH:60])[NH2:54])=[CH:49][CH:48]=5)=[N:4][C:5]=4[CH:10]=3)=[O:18])[CH3:44])=[CH:25][C:26]=2[N:30]=[C:29]1[CH2:31][NH:32][C:33]1[CH:34]=[CH:35][C:36]([C:39](=[NH:61])[NH2:40])=[CH:37][CH:38]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 517111Ammonium CarbonateHCID 698935551-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-(1-methylcyclopent-1-yl)ketone

Product 1

HCID 698937001-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-(1-methylcyclopent-1-yl) ketone hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-(1-methylcyclopent-1-yl)ketone, ethanolic hydrochloric acid, ethanol, and ammonium carbonate.

Sources & evidence

ORD record
ord-7d5b5cb76d1e4b89832837a57abc9adf
Source dataset
uspto-grants-2002_07
Patent number
US06414008B1

Reaction notes

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