Hydrochloric Acid → Iminoethyl methoxyacetate hydrochloride

HRID 2227680Notes

Reaction equation

HRID 2227680 reaction equation
[CH3:1][O:2][CH2:3][C:4]#[N:5].C([OH:8])C.[ClH:9].[CH2:10]([O:12][CH2:13]C)C>>[ClH:9].[CH3:10][O:12][CH2:13][C:1]([O:2][CH2:3][CH:4]=[NH:5])=[O:8]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 3283Diethyl EtherHCID 74442Methoxyacetonitrile

Product 1

HCID 57478929Iminoethyl methoxyacetate hydrochloride

Procedure

A solution of 35.5 g (0.50 mol) of methoxyacetonitrile in 29 ml (23 g, 0.50 mol) of ethanol and 30 ml of absolute diethylether was cooled to 0° C. and over 1 hour 22.5 g (0.62 mol) of hydrogen chloride gas was introduced, whilst towards the end of the introduction of gas the reaction product crystallized out. To complete the precipitation 130 ml of diethylether were added and the colorless needles were filtered off.

Workup

  1. additionwas introduced, whilst towards the end of the introduction of gas the reaction product
  2. customcrystallized out
  3. customthe precipitation 130 ml of diethylether
  4. additionwere added
  5. filtrationthe colorless needles were filtered off

Sources & evidence

ORD record
ord-645f36ea410f420d93665a48ee97a2eb
Source dataset
uspto-grants-2002_07
Patent number
US06414008B1

Reaction notes

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