Bromine → 1-Bromo-3,5-di-tert-butylbenzene

HRID 2227686Notes

Reaction equation

HRID 2227686 reaction equation
[Br:1]Br.[C:3]([C:7]1[CH:8]=[C:9](O)[CH:10]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:12]=1)([CH3:6])([CH3:5])[CH3:4]>C(#N)C>[Br:1][C:9]1[CH:8]=[C:7]([C:3]([CH3:6])([CH3:5])[CH3:4])[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:10]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 708253,5-Di-tert-butylphenol

Product 1

HCID 6201361-Bromo-3,5-di-tert-butylbenzene

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

After bromine addition, the ice bath was removed. 124 g of 3,5-di-tertbutylphenol (601 mmol) and 140 mL acetonitrile were added in one portion. The orange/white suspension converted into an orange solution upon heating. The mechanical stirrer was replaced by an egg-shape stir bar. The solution was stirred at gentle reflux temperature for three hours.

Workup

  1. customthe ice bath was removed
  2. temperatureupon heating
  3. stirringThe solution was stirred at gentle reflux temperature for three hours

Sources & evidence

ORD record
ord-8559be7d3f3f4987a482fce4cb49966d
Source dataset
uspto-grants-2002_07
Patent number
US06414095B1

Reaction notes

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