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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 222770생성일: 2026년 10월 25일

(3-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)boronic acid → 1,1-Dimethylethyl 7-({2-cyano-4-[(methylamino)carbonyl]phenyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

https://huagongshe.com/reaction/222770

반응식

참여 물질

역할이름HCID투입량
반응물(3-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)boronic acidHCID 57440296—
반응물3-Cyano-4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylbenzamideHCID 57440313—
생성물1,1-Dimethylethyl 7-({2-cyano-4-[(methylamino)carbonyl]phenyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylateHCID 68508039—

반응 단계

The title compound was prepared from 3-cyano-4-hydroxy-N-methylbenzamide (E279, Step 3) and (3-{[(1,1-dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)boronic acid (E264, Step 2), using the method of Example 264 Step 3; MS (ES+) m/e 322 [(M+H)—CO2tBu]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08207331B2
출처 데이터셋uspto-grants-2012_06
ORD IDord-5ab09c9346234ec5898aeff55639c189
출처 메모uspto-grants-2012_06