3-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[D]azepin-7-OL → HCID 57453924, compound

HRID 222775Notes

Reaction equation

HRID 222775 reaction equation
[CH:1]1([N:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[C:13]([OH:16])[CH:14]=[CH:15][C:8]=3[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.Cl[C:18]1[N:23]=[C:22]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[CH:21]=[N:20][CH:19]=1>>[CH:1]1([N:5]2[CH2:6][CH2:7][C:8]3[CH:15]=[CH:14][C:13]([O:16][C:18]4[CH:19]=[N:20][CH:21]=[C:22]([N:24]5[CH2:25][CH2:26][O:27][CH2:28][CH2:29]5)[N:23]=4)=[CH:12][C:9]=3[CH2:10][CH2:11]2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 100820813-Cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[D]azepin-7-OLHCID 263702094-(6-Chloropyrazin-2-yl)morpholine

Product 1

HCID 57453924HCID 57453924, compound

Procedure

Example (E288) was prepared from 3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol (E3) and 4-(6-chloro-2-pyrazinyl)morpholine [Zagulyaeva, O. A., J. Org. Chem. USSR, EN, 14; 1978; 377-380] using an analogous method to that described for Example 242 (E242); MS (ES+) m/e 381 [M+H]+.

Sources & evidence

ORD record
ord-3c0b3de491d749bfaa43a01022126f11
Source dataset
uspto-grants-2012_06
Patent number
US08207331B2

Reaction notes

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