反应详情

N-benzyl-4-hydroxyphenethylamine (J. Het. Chem., p. 839, 1971; 7.26 g, 0.032 mol) and 6-chloronicotinamide (5.0 g, 0.032 mol)were dissolved in 180 ml of dimethylacetamide and heated to reflux while water was collected in a Dean-Stark trap prefilled with isooctane. The reaction was refluxed under nitrogen for 17 hrs and additional 6-chloronicotinamide (1 g) added. After 2 hours, the solvent was removed in vacuo and the residue dissolved in 125 ml of ethyl acetate. The solution was shaken with dilute HCl and the solids collected by filteration (8.2 g). NMR.

1. temperatureheated
2. customwas collected in a Dean-Stark trap
3. temperatureThe reaction was refluxed under nitrogen for 17 hrs
4. additionadditional 6-chloronicotinamide (1 g) added
5. customthe solvent was removed in vacuo
6. dissolutionthe residue dissolved in 125 ml of ethyl acetate
7. customthe solids collected by filteration (8.2 g)