反应详情

温度

110 °C

A mixture of N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine (185 g, 1 mole), potassium hydroxide (112 g, 2 moles) and 1-fluoronaphthalene (146 g, 1 mole) in dimethylsulfoxide (1000 ml) is stirred at 110° C. for 2 hours. After cooling down to 20° C., the mixture is filtered, diluted with water (3 l), D-tartaric acid (75 g, 0.5 mole) is added and the mixture is stirred at 80° C. for 0.5 hour. After cooling down, the precipitated product is sucked off, washed with water and dried. Yield: 313 g (81%).

1. temperatureAfter cooling down to 20° C.
2. filtrationthe mixture is filtered
3. additionis added
4. stirringthe mixture is stirred at 80° C. for 0.5 hour
5. temperatureAfter cooling down
6. washwashed with water
7. customdried