Sodium Cyanide → HCID 54415491, compound

HRID 22279Notes

Reaction equation

HRID 22279 reaction equation
Cl[CH2:2][C:3]([O:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([NH:13][C:14]2[CH:18]=[CH:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:15]=2)=[CH:8][C:7]=1[CH3:25])=[O:4].[C-:26]#[N:27].[Na+]>CS(C)=O>[C:26]([CH2:2][C:3]([O:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([NH:13][C:14]2[CH:18]=[CH:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:15]=2)=[CH:8][C:7]=1[CH3:25])=[O:4])#[N:27]

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 498248502,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl chloroacetate

Product 1

HCID 54415491HCID 54415491, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

2,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl chloroacetate, Example 4k, (1 g) and sodium cyanide (0.5 g) stirred in dimethyl sulfoxide for 16 hours gave, after dilution with brine, extraction with ethyl acetate and subsequent evaporation, the title compound (0.3 g), mp 116°-117° (from ethyl acetate/hexane).

Workup

  1. customgave
  2. extractionafter dilution with brine, extraction
  3. customwith ethyl acetate and subsequent evaporation

Sources & evidence

ORD record
ord-aea71330bab44cafb3bd1629fffe2846
Source dataset
uspto-grants-1995_06
Patent number
US05428044

Reaction notes

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