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HRID22279

反应详情

EQUATION

反应方程式

HRID 22279 的结构方程式

REACTANTS

反应物

2
结构：[C-]#N.[Na+]
HCID8929

Sodium cyanide (Na(CN))

CNNa

结构：Cc1cc(Nc2ccn(-c3ccccc3)n2)cc(C)c1OC(=O)CCl
HCID49824850

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(Nc2ccn(-c3ccccc3)n2)cc(C)c1OC(=O)CC#N
HCID54415491

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

2,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl chloroacetate, Example 4k, (1 g) and sodium cyanide (0.5 g) stirred in dimethyl sulfoxide for 16 hours gave, after dilution with brine, extraction with ethyl acetate and subsequent evaporation, the title compound (0.3 g), mp 116°-117° (from ethyl acetate/hexane).

WORKUP

后处理

  1. customgave
  2. extractionafter dilution with brine, extraction
  3. customwith ethyl acetate and subsequent evaporation