Imidazole → 2-(Imidazol-1-yl)-1-(thiazol-2-yl)-ethanone

HRID 2227985Notes

Reaction equation

HRID 2227985 reaction equation
Br[CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][N:9]=1)=[O:4].[NH:10]1[CH:14]=[CH:13][N:12]=[CH:11]1>CC#N>[N:10]1([CH2:2][C:3]([C:5]2[S:6][CH:7]=[CH:8][N:9]=2)=[O:4])[CH:14]=[CH:13][N:12]=[CH:11]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 27952122-Bromo-1-(1,3-thiazol-2-yl)ethan-1-one

Product 1

HCID 223249842-(Imidazol-1-yl)-1-(thiazol-2-yl)-ethanone

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 2-bromo-1-(thiazol-2-yl)-ethanone (2.5 g; 12 mmol) in CH3CN (70 ml) was added imidazole (1.65 g; 24 mmol). After stirring at room temperature for 1 hour, the mixture was evaporated to dryness and partitioned between CH2Cl2 and water. The organics were washed with saturated NaCl and evaporated to give 2-(imidazol-1-yl)-1-(thiazol-2-yl)-ethanone as a brown solid (1.17 g; 50%).

Workup

  1. customthe mixture was evaporated to dryness
  2. custompartitioned between CH2Cl2 and water
  3. washThe organics were washed with saturated NaCl
  4. customevaporated

Sources & evidence

ORD record
ord-1435ee3ee7924a32aae9baa5478f7dea
Source dataset
uspto-grants-2002_07
Patent number
US06414145B1

Reaction notes

Loading…