HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 2-(Imidazol-1-yl)-1-(thiazol-2-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 2-Bromo-1-(1,3-thiazol-2-yl)ethan-1-one | HCID 2795212 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(Imidazol-1-yl)-1-(thiazol-2-yl)-ethanone | HCID 22324984 | — |
Reaction Steps
To a solution of 2-bromo-1-(thiazol-2-yl)-ethanone (2.5 g; 12 mmol) in CH3CN (70 ml) was added imidazole (1.65 g; 24 mmol). After stirring at room temperature for 1 hour, the mixture was evaporated to dryness and partitioned between CH2Cl2 and water. The organics were washed with saturated NaCl and evaporated to give 2-(imidazol-1-yl)-1-(thiazol-2-yl)-ethanone as a brown solid (1.17 g; 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06414145B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-1435ee3ee7924a32aae9baa5478f7dea |
| Source note | uspto-grants-2002_07 |