Sodium Hydroxide → HCID 54378381, compound

HRID 2227986Notes

Reaction equation

HRID 2227986 reaction equation
[N:1]1([CH2:6][C:7]([C:19]2[S:20][CH:21]=[CH:22][N:23]=2)=[CH:8][C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=2)[C:12]([O:14]C)=[O:13])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH-].[Na+]>CO>[N:1]1([CH2:6][C:7]([C:19]2[S:20][CH:21]=[CH:22][N:23]=2)=[CH:8][C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=2)[C:12]([OH:14])=[O:13])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53680105HCID 53680105, compound

Product 1

HCID 54378381HCID 54378381, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of step C) (2.6 g; 8 mmol) in solution in MeOH (60 ml) was treated with NaOH 2N, (8 ml; 16 mmol) at room temperature for 2 hours. After evaporation of the methanol, the residue was acidified to pH 6 with HCl 6N, to precipitate a solid which was washed with water and ether to give 3-(3-(imidazol-1-yl)-2-(thiazol-2-yl)-prop-1-enyl)benzoic acid as a mixture of E and Z isomers (2 g; 80%).

Workup

  1. customAfter evaporation of the methanol
  2. customto precipitate a solid which
  3. washwas washed with water and ether

Sources & evidence

ORD record
ord-dab636040e3540ffa58582c9667d29dd
Source dataset
uspto-grants-2002_07
Patent number
US06414145B1

Reaction notes

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