Sodium Hydroxide → HCID 54378381, compound

Participants

Reaction Steps

The product of step C) (2.6 g; 8 mmol) in solution in MeOH (60 ml) was treated with NaOH 2N, (8 ml; 16 mmol) at room temperature for 2 hours. After evaporation of the methanol, the residue was acidified to pH 6 with HCl 6N, to precipitate a solid which was washed with water and ether to give 3-(3-(imidazol-1-yl)-2-(thiazol-2-yl)-prop-1-enyl)benzoic acid as a mixture of E and Z isomers (2 g; 80%).

Provenance & Evidence