huagongshe.com
HRID2227992

反应详情

EQUATION

反应方程式

HRID 2227992 的结构方程式

REACTANTS

反应物

2
结构：Cc1cncn1CC(=O)c1ccc(F)cc1
HCID18474644

未命名化合物

结构：COC(=O)c1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1-c1ccccc1.[Br-]
HCID86590333

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1ccc(C=C(Cn2cncc2C)c2ccc(F)cc2)cc1-c1ccccc1
HCID54032621

未命名化合物

收率 76%

PROCEDURE

实验过程

Product from step E was reacted with 1-(4-fluorophenyl)-2-(5-methylimidazol-1-yl)-ethanone using methodology as described in Example 4, compound a), step B and purified by flash chromatography eluting with CH2Cl2/EtOH (93/7) to give methyl 4-[2-(4-fluorophenyl)-3-(5-methylimidazol-1-yl)-prop-1-enyl]-2-phenyl-benzoate as an oil. Yield=76%.

WORKUP

后处理

  1. custompurified by flash chromatography
  2. washeluting with CH2Cl2/EtOH (93/7)