HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Fluorophenyl)-2-(5-methylimidazol-1-yl)-ethanone → Methyl 4-[2-(4-fluorophenyl)-3-(5-methylimidazol-1-yl)-prop-1-enyl]-2-phenyl-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Fluorophenyl)-2-(5-methylimidazol-1-yl)-ethanone | HCID 18474644 | — |
| Reactant | 4-Methyloxycarbonyl-3-phenyl-benyl-triphenylphosphonium bromide | HCID 86590333 | — |
| Product | Methyl 4-[2-(4-fluorophenyl)-3-(5-methylimidazol-1-yl)-prop-1-enyl]-2-phenyl-benzoate | HCID 54032621 | 76% |
Reaction Steps
Product from step E was reacted with 1-(4-fluorophenyl)-2-(5-methylimidazol-1-yl)-ethanone using methodology as described in Example 4, compound a), step B and purified by flash chromatography eluting with CH2Cl2/EtOH (93/7) to give methyl 4-[2-(4-fluorophenyl)-3-(5-methylimidazol-1-yl)-prop-1-enyl]-2-phenyl-benzoate as an oil. Yield=76%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06414145B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-673f8ead15b9438fa5f9149d6864b2bf |
| Source note | uspto-grants-2002_07 |