HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-[3-(Imidazol-1-yl)-2-(thiazol-2-yl)-propyl]-2-phenyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | methyl 4-[(Z)-3-(imidazol-1-yl)-2-(thiazol-2-yl)-prop-1-enyl]-2-phenyl-benzoate | HCID 70030731 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[3-(Imidazol-1-yl)-2-(thiazol-2-yl)-propyl]-2-phenyl-benzoic acid | HCID 18474580 | — |
Reaction Steps
Product from step B (0.39 g; 0.96 mmol) and NaOH 2N, (1.25 ml) in MeOH (8 ml) was heated at reflux for 2 hours. After evaporation of the solvent and neutralisation at pH6, the residue was purified on reverse phase silica eluting with MeOH/(NH4)2CO3 buffer (2 g/l, pH7) 20/80 to give 4-[3-(imidazol-1-yl)-2-(thiazol-2-yl)-propyl]-2-phenyl-benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06414145B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-5be8c18203614920a3fe21919f40318d |
| Source note | uspto-grants-2002_07 |