反应详情

A solution of Z isomer product from step D (0.64 g, 1.83 mmol) in MeOH (2 ml) was treated with 1N NaOH (2 ml). The resulting suspension was stirred at room temperature for 20 hrs and the acidity adjusted to pH 5 with 1N HCl. The solution was evaporated to dryness and the residue purified by chromatography isolute column (10 g, SiO2) with an eluent of dichloromethane/MeOH (9:1) to give 3-[(Z)-2-(4-fluorophenyl)-4-(imidazol-1-yl)-but-1-enyl]-benzoic acid 0.56 g, (91%) as a white solid.

1. customThe solution was evaporated to dryness
2. customthe residue purified by chromatography isolute column (10 g, SiO2) with an eluent of dichloromethane/MeOH (9:1)