HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 3-(4-Fluorophenyl)-4-methoxycarbonylbenzyl triphenylphosphonium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Methyl 4-bromomethyl-2-(4-fluorophenyl)benzoate | HCID 18399506 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(4-Fluorophenyl)-4-methoxycarbonylbenzyl triphenylphosphonium bromide | HCID 86590336 | 78% |
Reaction Steps
A solution of methyl 4-bromomethyl-2-(4-fluorophenyl)benzoate (12.85 g; 0.04 mol) and triphenyl phosphine (10.53 g; 0.04 mol) in toluene (230 ml) was treated at reflux for 3 hours. The resulting solid was filtered, washed with ether and pentane and dried to give 3-(4-fluorophenyl)-4-methoxycarbonylbenzyltriphenylphosphonium bromide (12.78 g, 78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06414145B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-1a108f6073914610aa5bae101482aef9 |
| Source note | uspto-grants-2002_07 |