HRID2228009

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

HCID18399506

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1-c1ccc(F)cc1.[Br-]

HCID86590336

未命名化合物

收率 78%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A solution of methyl 4-bromomethyl-2-(4-fluorophenyl)benzoate (12.85 g; 0.04 mol) and triphenyl phosphine (10.53 g; 0.04 mol) in toluene (230 ml) was treated at reflux for 3 hours. The resulting solid was filtered, washed with ether and pentane and dried to give 3-(4-fluorophenyl)-4-methoxycarbonylbenzyltriphenylphosphonium bromide (12.78 g, 78%).

WORKUP

后处理

temperatureat reflux for 3 hours
filtrationThe resulting solid was filtered
washwashed with ether and pentane
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1a108f6073914610aa5bae101482aef9
来源数据集: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06414145B1
来源说明: uspto-grants-2002_07

反应 SMILES

[Br:1][CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:4]=1.[C:20]1([P:26]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C=CC=CC=1>[Br-:1].[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:5]2[CH:4]=[C:3]([CH:12]=[CH:11][C:6]=2[C:7]([O:9][CH3:10])=[O:8])[CH2:2][P+:26]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[CH:14][CH:15]=1