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HRID2228017

反应详情

EQUATION

反应方程式

HRID 2228017 的结构方程式

REACTANTS

反应物

2
结构：[C-]#N.[K+]
HCID9032

Potassium cyanide

CKN

结构：Cc1cc(OS(=O)(=O)C(F)(F)F)cc(-c2ccccc2)c1
HCID18474574

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C#N)cc(-c2ccccc2)c1
HCID18474544

未命名化合物

收率 20%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A mixture of 3-trifluoromethanesulfonyloxy-5-phenyltoluene (35.6 g; 0.128 mol), tetrakis(triphenylphosphine)palladium (12 g; 0.01 mol) and KCN (15.11 g; 0.23 mol) in dioxan (300 ml) was heated at reflux under argon an atmosphere for 24 hours. After extraction with ether and evaporating, the residue was purified by flash chromatography eluting with petroleum ether/ethyl acetate (84/6) to give 3-cyano-5-phenyltoluene. Yield=20%.

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureat reflux under argon an atmosphere for 24 hours
  3. extractionAfter extraction with ether
  4. customevaporating
  5. customthe residue was purified by flash chromatography
  6. washeluting with petroleum ether/ethyl acetate (84/6)