反应详情

A mixture of methyl 2-(4-fluorophenethyl)-5-bromomethylbenzoate (2.5 g; 7.1 mmol) and triphenylphosphine (2.1 g; 7.9 mmol) in toluene (50 ml) was heated at reflux for 3 hours. The solvent was evaporated and the residue was triturated in diethyl ether, filtered and washed three times with diethylether to give 3-methoxycarbonyl-4-[2-(4-fluorophenyl)ethyl]benzyl triphenylphosphonium bromide as a white solid. Yield=96%.

1. temperaturewas heated
2. temperatureat reflux for 3 hours
3. customThe solvent was evaporated
4. customthe residue was triturated in diethyl ether
5. filtrationfiltered
6. washwashed three times with diethylether