Methyl iodide → HCID 18472330, compound

HRID 2228063Notes

Reaction equation

HRID 2228063 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH2:23][CH2:22][C:21]3[C:16](=[CH:17][C:18]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:19][CH:20]=3)[CH:15]=2)=[O:13])=[CH:7][CH:6]=1)[CH3:3].[CH3:30][I:31]>CN(C=O)C>[I-:31].[CH3:3][N+:2]([CH3:30])([CH3:1])[CH2:4][C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]([C:14]2[CH2:23][CH2:22][C:21]3[C:16](=[CH:17][C:18]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:19][CH:20]=3)[CH:15]=2)=[O:13])=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18472372HCID 18472372, compound

Product 1

HCID 18472330HCID 18472330, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In DMF (2 ml) was dissolved N-[4—(dimethylaminomethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide (80 mg), and to the mixture was added methyl iodide (39 μl). The mixture was stirred at room temperature for 17 hours and concentrated under reduced pressure. The residue was recrystallized from methanol-ethyl acetate to give trimethyl[4—(7-phenyl-3,4-dihydronaphthalene-2-carboxamido)benzyl]ammonium iodide (Compound 10) (92 mg) as colorless crystals.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was recrystallized from methanol-ethyl acetate

Sources & evidence

ORD record
ord-9b061ffa71b8435bb01a48c70dba5456
Source dataset
uspto-grants-2002_07
Patent number
US06413947B1

Reaction notes

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