反应详情

温度

70 °C

In DMF (3 ml) was dissolved N-[4—(chloromethyl)-phenyl]7-phenyl-3,4-dihydronaphthalene-2-carboxamide (160 mg). and to the mixture was added 3-cyanopyridine (133 mg). The mixture was stirred at 70° C. for 24 hours and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-methanol to give 3-cyano-1-[4—(7-phenyl-3,4-dihydro-naphthalene-2-carboxamido)benzyl]pyridinium chloride (Compound 22) (58 mg) as pale orange crystals.

1. concentrationconcentrated under reduced pressure
2. customThe residue was recrystallized from ethyl acetate-methanol