反应详情

A 40 g (239 mmol) portion of δ-aminolevulinic acid hydrochloride and 18 ml (263 mmol) of 85% phosphoric acid were dissolved in 120 ml of purified water, and 25.4 g mmol) of triethylamine was added dropwise thereto while stirring on an ice bath. After completion of the dropwise addition and subsequent stirring at room temperature for 10 minutes, 1.6 L of ethanol was added thereto and stirred. The thus precipitated precipitate was recovered by suction filtration and dried at room temperature for 16 hours under a reduced pressure. A 51 g (224 mmol) portion of δ-aminolevulinic acid phosphate was obtained at a yield of 93 mol %.

1. additionAfter completion of the dropwise addition
2. stirringsubsequent stirring at room temperature for 10 minutes
3. stirringstirred
4. filtrationThe thus precipitated precipitate was recovered by suction filtration
5. customdried at room temperature for 16 hours under a reduced pressure