HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 5-Methoxy-2-methylindan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-Methoxyindan-1-one | HCID 78787 | — |
| Catalyst | Pentacarbonyliron(0) | HCID 518773 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Methoxy-2-methylindan-1-one | HCID 12290490 | 44% |
Reaction Steps
5-Methoxy indanone was treated with aqueous formaldehyde in the presence of iron pentacarbonyl and KOH in ethanol according to G. Cainelli et. al., Tetrahedron Letters 27, 2491 (1973). After chromatography (hexane:ethylacetate=7:3) over SiO2, a 44% yield of white crystals was obtained (m.p. 73-76° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06416746B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-25fd0c8a62c34b399dc7840abb978e0e |
| Source note | uspto-grants-2002_07 |