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HRID2228345

反应详情

EQUATION

反应方程式

HRID 2228345 的结构方程式

REACTANTS

反应物

4
结构：C=O
HCID712

Formaldehyde

CH2O

结构：CCCCCC
HCID8058

n-Hexane

C6H14

结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：COc1ccc2c(c1)CCC2=O
HCID78787

5-Methoxyindan-1-one

C10H10O2

PRODUCTS

生成物

1
结构：COc1ccc2c(c1)CC(C)C2=O
HCID12290490

未命名化合物

收率 44%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[Fe]
催化剂HCID518773

未命名化合物

结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

5-Methoxy indanone was treated with aqueous formaldehyde in the presence of iron pentacarbonyl and KOH in ethanol according to G. Cainelli et. al., Tetrahedron Letters 27, 2491 (1973). After chromatography (hexane:ethylacetate=7:3) over SiO2, a 44% yield of white crystals was obtained (m.p. 73-76° C.).