反应详情

A mixture of 15.4 ml (240 mmol) of propargyl amine and 17.1 ml (160 mmol) of ethyl cyano acetate was heated for 7 hours to 40° C. in a reaction flask. The crystalline material formed was heated for another 17 hours to 70° C. Then, the cooled reddish product was dried at high vacuum to yield 18.4 g (94%) of a red powder, m.p. 100-103° C.

1. temperaturewas heated for 7 hours to 40° C. in a reaction flask
2. customThe crystalline material formed
3. temperaturewas heated for another 17 hours to 70° C
4. customThen, the cooled reddish product was dried at high vacuum