反应详情

温度

26 °C

Ethyl (2R, 3R)-2-acetylamino-3-hydroxyoctadecanoate (1.00 g, 2.59 mmol) synthesized in the same method as Example 13 was suspended in an ethanol solution of about 30 wt % of hydrogen chloride, and the mixture was stirred for 15.5 hours in refluxing condition. After ethanol (10.0 mL) was added thereto, the mixture was cooled to 26° C. The precipitated solid was filtered to obtain 0.61 g of the title compound (yield: 62%).

1. temperaturein refluxing condition
2. filtrationThe precipitated solid was filtered