Bromine → 2-(4-Bromophenyl)ethanol

HRID 2228375Notes

Reaction equation

HRID 2228375 reaction equation
C([C:4]1[CH:15]=[CH:14][C:7]([CH2:8][CH:9]([OH:13])[SiH](C)C)=[CH:6][CH:5]=1)C=C.[Br:16]Br>C(O)CC1C=CC=CC=1>[Br:16][C:4]1[CH:15]=[CH:14][C:7]([CH2:8][CH2:9][OH:13])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 131723369HCID 131723369, compound

Product 1

HCID 728512-(4-Bromophenyl)ethanol

Reagents, catalysts & solvents 1

HCID 60542-PhenylethanolSolvent

Procedure

Hydroboration of 4-allyldimethylsilylphenethyl alcohol (1 Scheme 8) followed by Suzuki coupling reaction with the linker (2 Scheme 29) resulted in polymer-bound phenethyl alcohol compound (3 Scheme 29) which can be cleaved with bromine to give 4-bromophenethyl alcohol (4 Scheme 29).

Workup

  1. customreaction with the linker (2 Scheme 29)

Sources & evidence

ORD record
ord-a959eb06afea4e51a27ab0d8452ea9f5
Source dataset
uspto-grants-2002_07
Patent number
US06416861B1

Reaction notes

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