反应详情

To 300 mg of methyl 4-carboxymethyl-2-methoxy-benzoate from preparation 1 placed in 6 mL of acetic acid, are added 110 μL of sulfuryl chloride (1 equivalent). The whole is refluxed for 6 hours. After evaporation of the solvent, the reaction crude product is purified on silica gel (petroleum ether/ethyl acetate: 80/20 then 60/40) leading to 165 mg of the desired compound.

1. temperatureThe whole is refluxed for 6 hours
2. customAfter evaporation of the solvent
3. customthe reaction crude product
4. customis purified on silica gel (petroleum ether/ethyl acetate