HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → Methyl 5-chloro-4-carboxymethyl-2-methoxy-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 2-(3-Methoxy-4-(methoxycarbonyl)phenyl)acetic acid | HCID 10822993 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Methyl 5-chloro-4-carboxymethyl-2-methoxy-benzoate | HCID 68967398 | — |
Reaction Steps
To 300 mg of methyl 4-carboxymethyl-2-methoxy-benzoate from preparation 1 placed in 6 mL of acetic acid, are added 110 μL of sulfuryl chloride (1 equivalent). The whole is refluxed for 6 hours. After evaporation of the solvent, the reaction crude product is purified on silica gel (petroleum ether/ethyl acetate: 80/20 then 60/40) leading to 165 mg of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207373B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-06769f0d1185415495eb12682526afc1 |
| Source note | uspto-grants-2012_06 |